Tyson, who recently toured his one-man autobiographical stage show, "Mike Tyson: Undisputed Truth," will give voice to his cartoon character on the "Mike Tyson Mysteries" crime-solving series.
Tyson, 46, will be aided by a magical tattoo on his character's face and a foul-mouthed pigeon as a partner on the 15-minute show, Adult Swim said. Tyson in real life owns racing pigeons.
The network, which is known for its zany youth-oriented programs, did not say when the show would premiere.
Some plot lines include attempting to defeat a super computer at chess and why an author/werewolf cannot finish a novel, Adult Swim said.
Tyson, who became better known for his erratic behavior and 1992 rape conviction than for his skill in the ring, has seen his reputation rise following a cameo in the 2009 hit comedy "The Hangover."
Tyson retired from boxing in 2006 and began a second career in entertainment, including a 2011 television documentary series about his flock of racing pigeons.
Adult Swim is owned by Turner Broadcasting System Inc, a subsidiary of Time Warner Inc.
(Reporting by Eric Kelsey; Editing by Philip Barbara)